The Millennium Biltmore Hotel, originally named the Los Angeles Biltmore Hotel of the Biltmore Hotels group, is a luxury hotel located across the street from Pershing Square in Downtown Los Angeles, California, US. Upon its grand opening in 1923, the Los Angeles Biltmore was the largest hotel west of Chicago, Illinois in the United States. In 1969 the Biltmore Hotel was designated a Los Angeles Historic-Cultural Monument by the City of Los Angeles. Regal Hotels purchased the Biltmore in 1996, and then sold it in 1999 to Millennium & Copthorne Hotels. As of 2009, the Los Angeles Biltmore is operated as part of the Millennium & Copthorne Hotels chain as the Millennium Biltmore Hotel. The hotel has 70,000 square feet (6,500 m2) of meeting and banquet space. From its original 1500 guestrooms it now has 683, due to room reorganization.
It was part of the artistic inspiration for the imagineers designing The Twilight Zone Tower of Terror attraction in Florida.